Caryophyllene
แคริโอฟิลลีนWarm, spicy, and peppery with woody undertones. Like black pepper and cloves.
Only terpene known to directly bind and activate cannabinoid (CB2) receptors. FDA GRAS status.
โปรไฟล์กลิ่น
สรรพคุณทางการแพทย์
Anti-inflammatory (CB2 agonist)
หลักฐานแข็งแกร่งSelective CB2 receptor agonist (Ki = 155 nM). The only terpene that directly activates cannabinoid receptors.
First identification of BCP as a selective CB2 receptor agonist. First dietary cannabinoid identified.
Oral caryophyllene reduced PGE2, iNOS, and COX-2 expression. Effects comparable to dexamethasone.
Analgesic
หลักฐานแข็งแกร่งCB2-dependent pain reduction; effective for inflammatory and neuropathic pain without tolerance
Oral BCP reduced pain in CB2-dependent manner. No tolerance developed. More effective than synthetic CB2 agonist.
Anti-anxiety
หลักฐานปานกลางCB2 receptor activation modulating stress response
BCP reduced anxiety-like behaviors in both male and female rats with persistent pain.
ปฏิสัมพันธ์ (Entourage Effect)
Enhanced anti-inflammatory and analgesic effects through complementary pathways
preclinicalSynergistic anti-inflammatory effects; often found together naturally
preclinicalBalanced pain relief through CB1 + CB2 activation
preclinical
