Research-backed
🌤️
Cannabis for Depression
Limonene increases dopamine, serotonin, and norepinephrine — the three key neurotransmitters involved in depression. Pinene acts through the serotonergic 5-HT1A pathway, similar to conventional antidepressants. However, evidence for cannabis treating depression is still limited.
Recommended Terpenes
Supporting
The Science
Limonene increases dopamine, serotonin, and norepinephrine. Pinene acts via the 5-HT1A antidepressant pathway. Linalool inhibits serotonin reuptake. Caution: interaction with monoaminergic antidepressants needs further study.
Supporting Research
D-Limonene reduces depression-like behaviour via anti-neuroinflammatory mechanism
Alkanat, M. et al.
Eur J Neurosci (2024)
D-Limonene reduces depression-like behaviour and enhances learning and memory.
Pinene and Linalool as Terpene-Based Medicines for Brain Health
Weston-Green, K. et al.
Front Psychiatry (2021)
Beta-pinene produces antidepressant-like effect through 5-HT1A receptor interaction.
Important Considerations
- ⚠️ Limited overall evidence for cannabis treating depression
- ⚠️ May interact with existing antidepressant medications
Recommended Strains in Thailand
Chocolate Thai
THC 15–20% CBD 0.5–1%
euphoriccreativeuplifted
OG Kush
THC 19–26% CBD 0.3–0.7%
relaxedeuphorichappy
Thai Haze
THC 18–24% CBD 0.1–0.5%
euphoriccreativeenergetic
Amnesia Haze
THC 20–25% CBD 0.5–1%
euphoriccreativeenergetic
Thai Sativa
THC 12–18% CBD 0.5–1.5%
energeticcreativeuplifted
Thai Stick
THC 15–24% CBD 0.1–0.5%
euphoricenergeticcreative
Disclaimer: This information is for educational purposes only and does not constitute medical advice. Consult a licensed healthcare professional before using cannabis. Products with THC above 0.2% require a PT 33 prescription in Thailand.
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