Cannabis for Anxiety
CBD-dominant strains with specific terpenes like limonene and linalool show strong evidence for anxiety relief. A landmark 2024 Johns Hopkins study proved that limonene can even counteract THC-induced anxiety — the first clinical proof of the cannabis entourage effect.
Recommended Terpenes
The Science
Limonene is clinically proven to reduce THC-induced anxiety via A2A receptors. Linalool enhances GABA currents 2–7 fold — as effective as the SSRI paroxetine for GAD. Caryophyllene modulates stress via CB2.
Supporting Research
316 participants in 8 studies: CBD showed substantial impact on anxiety (Hedges' g = -0.92).
30 mg THC + 15 mg d-limonene significantly reduced anxiety vs THC alone.
Linalool-rich lavender oil (80 mg/day) was as effective as paroxetine 20 mg for generalized anxiety disorder.
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