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Humulene
SesquiterpeneSubtle, earthy hop-like aroma with woody, herbal notes. The scent of fresh hops.
Aroma Profile
earthy woody herbal
Medical Effects
Anti-inflammatory
Strong evidenceMechanism
COX-2 and iNOS inhibition; comparable to dexamethasone in preclinical models
Supporting studies
Anti-inflammatory effects of humulene and caryophyllene
Fernandes, E.S. et al.
Eur J Pharmacol (2007)
Humulene reduced COX-2 and iNOS expression. Anti-inflammatory effects comparable to dexamethasone.
Appetite suppressant
Moderate evidenceMechanism
Anorexigenic effects; counter to THC munchies
Antibacterial
Moderate evidenceMechanism
Disruption of bacterial cell membrane integrity
Synergies (Entourage Effect)
+
Humulene + Caryophyllene
Synergistic anti-inflammatory effects; naturally co-occur
preclinical
